Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including OmicronSARS-CoV-2 융합 억제 리포펩티드는 오미크론을 포함한 다양한 관심 변종에 대해 높은 효능을 유지합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity Alpha antiviral activity Beta broad-spectrum antiviral broad-spectrum antivirals Cell Cell fusion cell-cell fusion combating COVID-19 pandemic D614G Delta drugs effective vaccine Effective vaccines exhibited FIVE fusion inhibitor Gamma Impact Infection inhibiting inhibitor inhibitors Lambda lipopeptide maintain mutant omicron Omicron variant other variant other variants outbreak pseudovirus pseudovirus pseudovirus infection pseudoviruses reduced S protein S proteins SARS-CoV-2 significantly the S protein therapeutic variant variants variants of concern variants of concern. VoC VOCs wild-type WT virus [DOI] 10.1080/22221751.2022.2098060 PMC 바로가기 [Article Type] Article
A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccineArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome analysed antibody antibody titres BALB/c BALB/c mouse boost CD4 CD8 cellular cellular immunity coronavirus coronavirus disease COVID-19 COVID-19 vaccine Delta/B.1.617.2 variant of concern effective eight elicited emerging and re-Emerging coronaviruses glycoprotein homologous humoral Humoral immunity immunization Japanese LC16m8 less mice motif multifunctional neutralized Neutralizing activity patients with COVID-19 polybasic prime-boost immunization. provide recombinant replication-competent viral S-specific antibody S1/S2 cleavage site SARS-CoV-2 serum sample significantly lower Strains T-cell immune responses T-cell immunity T-cell Response the S protein Vaccine Vaccine development vaccine platform variant vector viral vectors virus Wuhan [DOI] 10.1080/22221751.2022.2122580 PMC 바로가기
Characterization and immunogenicity of SARS-CoV-2 spike proteins with varied glycosylationArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] 293 cells 293F cell acute respiratory syndrome addition binding caused Cell changed characterization convalescent sera coronavirus Coronavirus disease-19 COVID-19 Critical discrepancy effective Efficacy elicited exhibited expression globe glycosylated glycosylation glycosylation pattern homogeneity host cells IgG immunization immunogenicity insect cell mammalian cells mice Neutralizing antibody response neutralizing antibody titre pandemic Protein Proteins provide reactivity Receptor binding regimen robust S protein S-2P SARS-CoV-2 SARS-CoV-2 spike protein spike Spike. the S protein thermal stability Vaccine Vaccine design Variation virus virus entry while [DOI] 10.1016/j.vaccine.2022.09.057 PMC 바로가기
Critical pediatric neurological illness associated with COVID-19 (Omicron BA.2.3.7 variant) infection in Taiwan: immunological assessment and viral genome analysis in tertiary medical centerArticle Published on 2022-11-012022-11-16 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, [키워드] Amino acid amino acid variation cause cerebrospinal fluid children collected Complication COVID-19 COVID-19 infection diagnosed Encephalitis Epidemic explain immunological incidence increase in Infection Inflammatory marker Lineage medical record Mutation N-terminal domain nasal swab neurological Neurological complication Neurological symptom Neurological symptoms omicron Patient pediatric pediatric cases Pediatric patient Pediatric patients positive Protein reported SARS-CoV-2 sequence Sequencing Severe neurological symptoms spike Spike protein Strains Taiwan tested the S protein variant Variation viral genome analysis whole genome Whole genome sequencing whole genome sequencing. with COVID-19 [DOI] 10.1016/j.ijid.2022.09.001 PMC 바로가기
The mutation features and geographical distributions of the surface glycoprotein (S gene) in SARS-CoV-2 strains: A comparative analysis of the early and current strainsArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] ACE2-binding region acute respiratory syndrome Analysis analyzed coronavirus coronavirus disease COVID-19 COVID-19 vaccines demonstrated develop Evolution feature Frequency Genome genome mutations geographical distribution highest identify loci mutant strain Mutation omicron prevalent remained Result S gene S protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant strain Strains Surface glycoprotein Surface glycoprotein. the receptor-binding domain the S protein The United States United Kingdom Vaccines was used [DOI] 10.1002/jmv.28023 PMC 바로가기
Immune response after COVID-19 vaccination among patients with chronic kidney disease and kidney transplantArticle Published on 2022-10-262022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 진단, [키워드] adverse event Affect analyzed Anti-spike RBD IgG antibody antibody response against Blood Group Breakthrough infection cellular response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine chronic Chronic kidney disease CKD comparable Control controls Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 vaccination exhibited first dose group healthy controls Hemodialysis humoral Illness severity immune response immunological responses Inactivated vaccine incidence of COVID-19 individual injection kidney kidney transplant less lowest neutralizing antibody occurred outcome Patient patient group Peritoneal dialysis Protective RBD robust SARS-CoV-2 vaccine secondary single dose suggested T cell response the S protein the vaccine total population understanding vaccination Vaccine vaccine. virus neutralization test [DOI] 10.1016/j.vaccine.2022.09.067 PMC 바로가기
Construction and evaluation of a self-replicative RNA vaccine against SARS-CoV-2 using yellow fever virus repliconArticle Published on 2022-10-202022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome antibody Antigen C57BL/6 caused cells co-expressed construction coronavirus coronavirus disease COVID-19 effective vaccine Efficacy Electroporation elicit ENCODE ENhance evaluated Fever gene encoding Host host genome immune response Immunity IMPROVE Infection Innate immunity kidney mice mRNA vaccine pandemic Protein qRT-PCR Replication replicon responses RNA RNA vaccine robust S protein expression Safe SARS-CoV-2 significantly higher single dose Specific T-cell response T-cell Response the S protein Vaccine vaccine administration vaccine platform virus [DOI] 10.1371/journal.pone.0274829 PMC 바로가기
Early suppression of antiviral host response and protocadherins by SARS-CoV-2 Spike protein in THP-1-derived macrophage-like cellsArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Alpha Antiviral approved Cell cells cellular cellular response change coronavirus Coronavirus disease-19 COVID-19 cytokine differentially expressed downregulation Effect effort expressing expression highlight homeostasis host cells host response humoral immune responses induce Infection information interferon intrinsic involved medium pandemic pathogenic PROTECT Protein reflected Result S protein SARS-CoV-2 spike Spike protein the S protein transcriptomic transcriptomics transcriptomics. type I Vaccination strategies Vaccine variety while [DOI] 10.3389/fimmu.2022.999233 PMC 바로가기
Evolutionary Pattern Comparisons of the SARS-CoV-2 Delta Variant in Countries/Regions with High and Low Vaccine CoverageArticle Published on 2022-10-192022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accelerate caused Cluster co-mutation Coverage COVID-19 vaccine Delta delta variant dominant exhibited FIVE Frequency G142D Genetic genetic divergence genetic diversity Host immune immune evasion immune pressure Infection less Methylation Mutation ORF7a pattern Positive selection proportion SARS-CoV-2 sequence suggested the S protein the SARS-CoV-2 unique Vaccine vaccine coverage. variant Variation [DOI] 10.3390/v14102296 PMC 바로가기